Group 1 metabotropic glutamate receptors and schizophrenia
نویسندگان
چکیده
منابع مشابه
Group I Metabotropic Glutamate Receptors (mGlu1 and mGlu5)
The metabotropic glutamate (mGlu) receptors are a family of eight G protein-coupled receptors that modulate cell excitability and synaptic transmission in the nervous system. Group I mGlu receptors are generally coupled to Gq stimulation of phospholipase C and the release of intracellular calcium. The physiologic effects of group I mGlu receptors in the brain are diverse and highlight the impor...
متن کاملPositive and negative modulation of group I metabotropic glutamate receptors.
A discriminating pharmacophore model for noncompetitive metabotropic glutamate receptor antagonists of subtype 1 (mGluR1) was developed that facilitated the discovery of moderately active mGluR1 antagonists. One scaffold was selected for the design of several focused libraries where different substitution patterns were introduced. This approach facilitated the discovery of potent mGluR1 antagon...
متن کاملGroup III Metabotropic Glutamate Receptors (mGlu4, mGlu6, mGlu7, and mGlu8)
G protein-coupled group III metabotropic glutamate receptors (mGluRs) include four subtypes that are negatively coupled to adenylyl cyclase (mGluRs 4, 7, and 8) or positively to a cGMP phosphodiesterase (mGluR6). Typically, they exert inhibitory influences on neuronal activity. This chapter reviews the characteristics of group III mGluRs and their normal functions and role in nervous system dis...
متن کاملMetabotropic Glutamate Receptors
Metabotropic glutamate receptors (mGluR)s are G-protein-coupled receptors that function as modulators of synaptic function and glutamate transmission. Post-synaptically localized subtype 5 mGlu5 receptors are co-localized with adenosine A2a, dopamine, and N-methyl-D-aspartate (NMDA) receptors and regulate local protein synthesis and messenger RNA (mRNA) translation at synapses, and are thus ide...
متن کاملGroup I metabotropic glutamate receptors at GABAergic synapses in monkeys.
Recent data showed that group I metabotropic glutamate receptors (mGluRs) are located perisynaptic to the postsynaptic specializations of asymmetric glutamatergic synapses in the cerebellum and hippocampus in rats. In the present study, we used immunogold labeling to elucidate the subsynaptic localization of group I mGluRs (mGluR1a and mGluR5) in the internal and external segments of the globus...
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ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: Membrane Transport and Signaling
سال: 2011
ISSN: 2190-460X
DOI: 10.1002/wmts.15